According to the Annalsof Pharmacotherapy (2002) Glutamate, Aspartame and other artificial sweeteners can cause chronic pain sensitisation, and removing these products from the diet for 4 consecutive months can eliminate all chronic pain symptoms.

Artificial sweeteners can cause inflammatory responses in the body leading to chronic pain syndromes. As long as you are not a diabetic or have health issues that restrict you from consuming REAL sugar you should try to use raw, unrefined cane sugar as a sweetener. Although not as sweet as artificial sweeteners the real sugar is much easier for you body to figure out what to do with (metabolically).

Artificial Sweeteners can cause abnormal insulin reactions causing abnormal metabolic issues and leading to obesity as well.